Polyphenols and Neurodegenerative Diseases: Potential Effects and Mechanisms of Neuroprotection

The increase in people’s longevity has, consequently, led to more brain involvement and neurodegenerative diseases, which can become complicated lead chronic degenerative thereby presenting greater public health problems. Medicinal plants have been used since ancient times contain high concentrations of molecules, including polyphenols. It has proven that polyphenols, are present various natural sources provide curative effects against diseases disorders through neuroprotective effects. These mainly attributed their ability cross the blood–brain barrier, eliminate reactive oxygen species, cause chelation metal ions. Polyphenols concentration neurotrophic factors bind directly membrane receptors these factors, modulate activate signaling cascades allow plasticity, survival, proliferation, growth neuronal cells, allowing for better learning, memory, cognition. Moreover, polyphenols no serious adverse side resulting from consumption.